Neupatimagem UNICAMP

Pathology - Neuropathology - Neuroimaging
New additions (2015, 2016) ..

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Updated 5/1/2020	General and Special Pathology	e-mails : [email protected]____[email protected]
Neuropathology and Neuroimaging	Cases correlating Neuroimaging + Neuropathology	Neuroimaging Basics	Neuroimaging - Cases
Alphabetical index (Pathology)	Alphabetical index (Neuro)	Neuro Image Bank	Neuropathology - Cases
English Homepage	This page in Portuguese	New additions	Histopathological staining methods

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30/11/16
New Cases of Neuroimaging & Neuropathology:

M. 1 yr. 1 m. Atypical teratoid/rhabdoid tumor of right cerebral hemisphere. CT, MRI	Same, HE, text	Same, Masson's trichrome, reticulin	Same, immunohistochemistry for epithelial antigens - EMA, AE1AE3


Same, IH - glial antigens - GFAP, vimentin, S100	Same, IH - neuronal antigens - synaptophysin, MAP2, SMI-32	Same, IH - 1A4, CD34	Same, IH - INI1, Ki67, p53


Same, IH - CD68, HAM56, CD3, CD20		M. 7 yr. 2 m. Glioblastoma multiforme of thalamus, CT, MRI	Same, HE, text


M. 18 yr. Dysembryoplastic neuroepithelial tumor (DNT) of right inferior temporal / occipital gyri. CT, MRI	Same, HE	Same, LFB-Nissl	Same, IH - GFAP


Same, IH - MAP2	Same, IH - NeuN	Same, IH - SMI32, NF	Same, IH - synaptophysin, chromogranin, CD34, Ki67


M. 20 yr. Brain and lung metastases of testicular choriocarcinoma. CT, MRI	Same, contralateral brain metastases after one year. MRI	Same, immature teratoma of testis associated with choriocarcinoma, HE	Same, primary choriocarcinoma in testis, HE


Same, choriocarcinoma, first brain metastasis. HE, IH	Same, choriocarcinoma, second brain metastasis. Macro, HE

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31/8/16
New Cases of Neuroimaging & Neuropathology:

F. 2 yr. 2 m. Embryonal tumor with abundant neuropil and multilayered rosettes. CT, MRI	Same, specimen, HE, text	Same, immunohistochemistry for glial antigens - GFAP, vimentin	Same, immunohistochemistry for neuronal antigens - neurofilament, synaptophysin, MAP2, NeuN


Same, IH for EMA, Ki67		F. 4 yr. Diffuse anaplastic astrocytoma of pons. MRI	Same, HE


F. 8 yr. Ganglioglioma with pilocytic astrocytoma component in spinal cord, MRI	Same, HE	Same, IH for glial antigens - GFAP, vimentin	Same, IH for neuronal antigens - chromogranin, MAP2, SMI-32


Same, IH for CD34, Ki67		M. 11 yr. Glioblastoma multiforme of pons. MRI	Same, HE, GFAP, Ki67


M. 23 yr. Cystic ganglioglioma with minute solid component of pilocytic astrocytoma in cingulate gyrus. MRI	Same, HE	Same, IH - GFAP, chromogranin, CD34, Ki67


F. 72 yr. Cerebral amyloid angiopathy, parenchymatous and ventricular hemorrhage	Same, HE, Congo red	Same, Congo red under polarized light

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20/7/16
New Cases of Neuroimaging & Neuropathology:

F. 1 yr. 5 m. Hemimegalencephaly, agyria, pachygyria. MRI	Same, gross specimen	Same, HE	Same, LFB-Nissl


Same, immunohistochemistry for GFAP	Same, vimentin	Same, MAP2	Same, NeuN

		Texts. Agyria, pachygyria, hemimegalencephaly, meningeal glial heterotopia
Same, SMI-32	Same, CD34, Ki-67		F. 72 yr. Cerebellar liponeurocytoma , HE, texts : liponeurocytoma, rhythmic nuclear palisading


M. 20 yr. Ganglioglioma of head of caudate nucleus	Same, hypoplasia of vermis and cerebellar hemispheres	Same, HE, special stains	Same, IH for GFAP, VIM


Same, MAP2, NeuN	Same, SMI-32, chromogranin, synaptophysin	Same, CD34, Ki67


M. 15 yr. Atypical central neurocytoma of third ventricle	Same, HE, IH for glial antigens	Same, IH for neuronal antigens, CD34, Ki67


F. 24 yr. Desmoplastic medulloblastoma	Same, HE, reticulin	Same, IH, text: medulloblastomas

Neuro Image Bank. NNormal sympathetic ganglion

HE	Masson's trichrome, neurons	Same, sympathetic nerves	Reticulin


PAS	LFB-Nissl	MAP2	NF


SMI-32	Synaptophysin	Chromogranin	S-100

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5/5/16
New Cases of Neuroimaging & Neuropathology:

M. 4 yr. 4 m. Subependymal giant cell astrocytoma in tuberous sclerosis. MRI	Same, multiple tubers in cerebral hemispheres	Same, subependymal giant cell astrocytoma. HE, Masson's trichrome, reticulin silver stain	Same, immunohistochemistry for GFAP, VIM


Same, S-100, HAM 56, CD68	Same, NF, chromogranin, MAP2, CD56	Same, EMA, CD34, Ki67


M. 1 yr. 9 m. Tuberous sclerosis. Giant partly calcified fronto-parietal tuber, CT, MRI	Same, surgical specimen	Same, HE, Masson's, reticulin	Same, LFB-Nissl


Same, GFAP, VIM	Same, MAP2, chromogranin	Same, SNF, NF, SMI-32. Text	Same, CD34, Ki67


M. 23 yr. Frontal giant cell glioblastoma	Same, surgical specimen	Same, HE	Same, Masson's, reticulin


Same, GFAP, VIM	Same, S-100, CD56, NF	Same, CD34, Ki67


M. 25 yr. Neurofibromatosis type 2. Ependymomas in medulla and lumbar spinal cord. CT, MRI	Same, bilateral vestibular and right oculomotor schwannomas	Same, meningioma of optic nerve sheath, others	Same, surgical field and specimen


Same, HE	Same, IH - GFAP, VIM, EMA, NF, CD34, Ki-67


F. 55 yr. Fibroblastic S-100 positive meningiomas of posterior fossa raising schwannoma as differential diagnosis	Same, HE, IH - EMA, S-100	M. 74 yr. Fibroblastic S-100 positive meningioma of posterior fossa at internal auditory canal mimicking schwannoma	Same, HE, IH - EMA, S-100

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20/2/16
New Cases of Neuroimaging & Neuropathology:

M. 32 yr. Neurotuberculosis in rare presentation with symmetrical necrotizing vasculitis of midline cerebral cortex and corpus callosum	Same, HE, epithelioid and giant cell granuloma	Same, HE, acute necrotizing vasculitis with fibrin deposits and hemorrhagic infarction of cerebral cortex	Same, Masson's trichrome and Ziehl-Neelsen stain showing acid-fast bacilli in necrotic brain tissue


M. 63 yr. Fronto-temporal gliosarcoma	Same, specimen. Area of glioblastoma : HE, Masson's trichrome, Gomori's silver for reticulin fibers	Same, glioblastoma, immunohistochemistry for GFAP, neuronal antigens	Same, glioblastoma, IH for CD34, 1A4, Ki67, p53


Same, gliosarcoma, HE, Masson's trichrome, Gomori's silver for reticulin	Same, gliossarcoma, IH for GFAP, S-100, VIM	Same, gliossarcoma, IH for CD34, 1A4, Ki67, p53


M. 51 yr. Pilocytic astrocytoma of cerebellum with unusually luxuriant capillary proliferation (prompting differential diagnosis with hemangioblastoma)	Same, HE, GFAP. Pictured : astrocytoma islets amid proliferated capillaries	Same, CD34, Ki67, and differential diagnosis with hemangioblastoma : inhibin, NSE, S100


F. 67 yr. Pilocytic astrocytoma of retina	Same, HE, GFAP, VIM, S100, Ki67, text	M. 64 yr. Pseudotumoral paracoccidioidomycosis of cerebellum	Same, HE, Grocott, PAS


F. 21 yr. Fibrous dysplasia of skull	Same, specimen, HE, text	Same, Masson's trichrome

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27/12/15
New Cases of Neuroimaging & Neuropathology:

F. 62 yr. Cerebral bacterial abscess. 3 MRIs showing lesion regression with treatment	Same, massive subarachnoid hemorrhage one week after 3rd MRI	At autopsy - systemic aspergillosis. Gross appearance of brain	*Same, aspergillosis of brain (pictured - Aspergillus* phlebitis amid subarachnoid hemorrhage)**


Same, residual abscess cavity in white matter of superior temporal gyrus	Same, pulmonary aspergillosis. HE, Grocott	*Same, Aspergillus* abscesses in left ventricle. HE, Grocott. Hepatitis C liver cirrhosis**


F. 67 yr. Rhino-orbital aspergillosis	*Same, Aspergillus* in necrotic tissue of maxillary sinus and orbit. - HE, PAS, Grocott. Text**	*F. 31 yr. Cysticercosis cellulosae* of brain hemispheres and IV ventricle**	Same, IV ventricle cysticercus. Stereomicroscopic images, histology with degenerative changes


M. 8 mth. Congenital cerebral teratoma. 6 month follow up with CT, MRI	Same, 2nd. biopsy at 8 mth including nervous tissue and teeth. HE Text.	Same, 1st. biopsy at 2 mth showing only malformed brain tissue. Immunohistochemistry

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4/11/15
New Cases of Neuroimaging & Neuropathology:

F. 32 yr. Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos disease). MRI	Same, full blown changes, specimen, HE	Same, LFB-Nissl	Same, immunohistochemistry for MAP2, NeuN, synaptophysin
Lhermitte-Duclos: image bank, text

Same, IH for NF, chromogranin	Same, IH for GFAP, S100	Same, IH for CD34, CD68, Ki67	Same, partial changes, specimen, HE


Same, LFB-Nissl	Same, IH for MAP2, NeuN	Same, IH for GFAP, CD34, CD68, Ki67


M. 22 yr. Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos disease). MRI	Same, HE, LFB-Nissl	Same, IH for MAP2, NeuN, synaptophysin	Same, IH for NF, chromogranin


Same, IH for GFAP, CD34, Ki67	M. 22 yr. Same patient, normal cerebellar cortex. HE, LFB-Nissl	Same, IH for MAP2, NeuN, NF, synaptophysin	Same, IH for GFAP, S100, CD34


F. 45 yr. Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos disease). MRI - two distinct lesions in right cerebellar hemisphere	Same, HE, LFB-Nissl, lesions at different phases


M. 32 yr. Cerebral granulomatous cryptococcosis: circumscribed meningeal, cerebral lesions	Same, HE, Masson's trichrome, Grocott, mucicarmine, PAS		Cerebral cryptococcosis: non specific and granulomatous inflammation in meninges and parenchyma. HE, PAS

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5/10/15
New Cases of Neuroimaging & Neuropathology:

F. 6 yr 7 m. Angiocentric glioma in left superior frontal gyrus	Same, specimen, HE, text	Same, special stains	Same, IH for glial antigens


Same, IH for neuronal antigens	Same, IH for EMA, CD34, Ki67, p53	F. 57 yr. Primary cerebral vasculitis	Same, HE

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9/8/15
General Pathology - new pages for undergraduates:

Mallory's hyaline change in hepatocarcinoma cells	Hyaline nodules in glomeruli in diabetes mellitus (intercapillary glomerulosclerosis of Kimmelstiel-Wilson)	Acute tubular necrosis of kidney in shock	Diffuse amyloidosis of lymph node (pictured - Congo red stained section under polarized light)


Squamous metaplasia of trachea in prolonged intubation	Bone metaplasia of tracheal cartilage	Mammary fibroadenoma	Mammary adenocarcinoma

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10/7/15
Atlas of the normal human hippocampus
	HE	LFB-Nissl	MAP2
Index page

Neurofilament	Synaptophysin	Chromogranin	GFAP


Vimentin	CD34	CD68	HAM56


Texts (in Portuguese): Structure of the hippocampus, dentate gyrus, subiculum. Hippocampal connections and diagram.

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18/5/15
New Cases of Neuroimaging & Neuropathology:

F. 37 yr. Pituitary carcinoma with pulmonary metastases. 6-year follow up. CT, MRI, highlights	Same, exams in full. Text	Same, first biopsy of pituitary tumor, 2009. HE, IH	Same, second biopsy of pituitary tumor, 2015. HE, IH


Same, lung biopsy, 2014. HE, IH		F. 70 yr. Rathke's cleft cyst. MRI	Same, HE


F. 62 yr. Thoracic epidural meningeal cyst. MRI	Same, HE	M. 11 yr. 6 m. Intradural cervical and lumbar lipomas. MRI	Same, specimen, HE, Masson's trichrome, IH. Text


M. 36 yr. Fronto-parietal mesial pleomorphic xanthoastrocytoma	Same, HE	Same, IH - GFAP, VIM, S100, NF	Same, IH - CD34, CD99, 1A4, Ki67, p53


M. 11 yr. Frontal pleomorphic xanthoastrocytoma	Same, HE	Same, IH - GFAP, VIM	Same, IH - S100, NF, chromogranin, 1A4


Same, IH - CD34, CD99, Ki67, p53		M. 12 yr. Plexiform neurofibroma of tongue. HE, Masson's trichrome	Same, IH - NF, CD57, S100, EMA

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20/2/15
New Cases of Neuroimaging & Neuropathology:

F. 20 yr. Anaplastic and clear cell meningioma of posterior fossa with supratentorial extension. CT, MRI	Same, specimen, HE, anaplastic part	Same, HE, clear cell part	Same, Masson's trichrome


Same, reticulin, PAS in clear cell part, before and after amylase digestion	Same, immunohistochemistry for EMA, VIM	Same, IH, S-100, CD57, 1A4, HHF35. Pictured - axons in cranial nerve root infiltrated by tumor	Same, IH, CD34, Ki-67, p53


F. 26 days. Congenital anaplastic astrocytoma of temporal lobe. CT	Same, specimen, HE	Same, IH


F. 67 yr. Invasive pituitary adenoma with extensive skull base infiltration. CT, MRI	Same, HE, smear, paraffin sections	Same, IH. Pictured - invasive adenoma adjacent to respiratory epithelium


F. 22 yr. Cerebral metastases of choriocarcinoma 6 years after molar pregnancy. CT, MRI	Same, specimen, HE	Same, IH

Additions of 2004 to 2006

...

Updated 5/1/2020	General and Special Pathology	e-mails : [email protected]____[email protected]
Neuropathology and Neuroimaging	Cases correlating Neuroimaging + Neuropathology	Neuroimaging Basics	Neuroimaging - Cases
Alphabetical index (Pathology)	Alphabetical index (Neuro)	Neuro Image Bank	Neuropathology - Cases
English Homepage	This page in Portuguese	New additions	Histopathological staining methods

......